abstract：PURPOSE:Recent new reports of possible iatrogenic transmission of Creutzfeldt-Jakob disease (CJD) in Europe have prompted renewed scrutiny of current Eye Bank Association of America criteria for evaluation of potential corneal donors in this country. A prior study evaluated the risk of CJD occurring in U.S. corneal don...

journal_title：Cornea

authors： Hogan RN,Brown P,Heck E,Cavanagh HD

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:To describe a case of bilateral peripheral ulcerative keratitis after Salmonella gastroenteritis. METHODS:Case report with description of treatment and outcome. RESULTS:The peripheral ulcerative keratitis gradually resolved in both eyes after appropriate systemic antibiotic therapy and local ocular care. CON...

journal_title：Cornea

authors： Yang J,Baltatzis S,Foster CS

更新日期：1998-11-01 00:00:00

abstract：PURPOSE:To study two cases of corneal scarring due to trauma (one case) and infection (one case) unrelated to a previous photorefractive keratectomy (PRK) for the correction of myopia. METHODS:The patients are part of an Institutional Review Board-approved study of the safety and efficacy of PRK. Both patients underwe...

journal_title：Cornea

authors： Campos M,Takahashi R,Tanaka H,Chamon W,Allemann N

更新日期：1998-11-01 00:00:00

abstract：PURPOSE:To evaluate changes in the donor corneal endothelium in the intact globe and in the in vivo rabbit cornea to characterize more fully the formation of "dark events" without relief images in the endothelial mosaic. METHODS:Six ex vivo human donor corneas in the intact globe and an in vivo rabbit model were used ...

journal_title：Cornea

authors： Nartey IN,Cavanagh HD,Jester JV,Andrews P,Petroll WM

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:To evaluate the morphometric and fluorophotometric characteristics of corneal endothelium after an eight-incision radial keratotomy (RK). METHODS:A total of 43 eyes of 26 patients underwent RK and 44 eyes of 23 patients were used as age-matched controls. All patients underwent specular microscopic and fluoroph...

journal_title：Cornea

authors： Tseng SH,Chen FK

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:This study investigated the topographic corneal thickness in four groups of Hong Kong Chinese. METHODS:The corneal thickness was determined with an ultrasound pachometer mounted on a X-Y plate. A head rest was used to reduce further any movement from the subject during the measurement. After the central cornea...

journal_title：Cornea

authors： Lam AK,Douthwaite WA

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:To describe the clinical features, histopathology, surgical management and possible etiopathogenesis of corneoscleral epithelial cysts. METHODS:Three patients with corneoscleral epithelial cysts underwent surgical ablation of the cysts. Material obtained during surgery was subjected to histopathologic analysis...

journal_title：Cornea

authors： Rao SK,Fogla R,Biswas J,Padmanabhan P

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:To describe a distinct and unusual superficial dendriform keratopathy that can be seen in postkeratoplasty eyes. METHOD:Three Caucasian women in their sixth decade of life were referred to the Corneal and External Disease Service at the University of California, Davis, and underwent penetrating keratoplasty fo...

journal_title：Cornea

authors： Mannis MJ,Garcia-Ferrer FJ,Davitt S

更新日期：1998-05-01 00:00:00

abstract：PURPOSE:Pseudophakic/aphakic bullous keratopathy (PBK/ABK) human corneas accumulate an extracellular matrix glycoprotein tenascin-C (TN-C), an important modulator of cell adhesion and migration. Here, the purpose was to identify specific TN-C mRNA splice variants in normal and PBK/ABK human corneas. METHODS:Convention...

journal_title：Cornea

authors： Saghizadeh M,Khin HL,Bourdon MA,Kenney MC,Ljubimov AV

更新日期：1998-05-01 00:00:00

abstract：PURPOSE:To determine the relationships among endothelial morphometric variables and contact lens-induced corneal swelling in a homogeneous sample of adapted contact-lens wearers. METHODS:Fifteen male subjects ranging in age from 20 to 40 years, all adapted to daily wear of hydrogel lenses, wore uniform-thickness lense...

journal_title：Cornea

authors： Erickson P,Doughty MJ,Comstock TL,Cullen AP

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:We report two patients with primary graft failure (PGF) from a mutual donor. The surgery in each case was done by a different surgeon experienced in penetrating keratoplasty (PK). The cases were managed differently in the postoperative period with good visual results in both cases. We discuss the various manage...

journal_title：Cornea

authors： Van Rensburg PD,Raber IM,Laibson PR,Eagle RC Jr

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:Clinical research addressing the issue of donor globe decontamination is yet to establish convincing data for the optimal choice of an antimicrobial agent. METHODS:In a donor-globe decontamination study, the antimicrobial effectiveness of a fluoroquinolone antibiotic (ciprofloxacin, 0.3%) was evaluated for the...

journal_title：Cornea

authors： Gopinathan U,Reddy MK,Nadkarni MS,Dasari S,Rao GN

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:To report a 64-year-old woman's case of infectious crystalline keratopathy (ICK) that occurred 9 years after the penetrating keratoplasty (PKP). METHODS:This study includes clinical history and histopathologic findings of the case. RESULTS:As historic background, the patient underwent PKP for lattice dystroph...

journal_title：Cornea

authors： Matsumoto A,Sano Y,Nishida K,Yokoi N,Hara J,Kinoshita S

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:To identify changing trends in indications for penetrating keratoplasty and associated surgical procedures. METHODS:Review of charts from all patients who underwent penetrating keratoplasty at Wills Eye Hospital from January 1, 1989 through December 31, 1995. RESULTS:A total of 2,442 corneal transplants were ...

journal_title：Cornea

authors： Lois N,Kowal VO,Cohen EJ,Rapuano CJ,Gault JA,Raber IM,Laibson PR

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:To determine the prevalence of hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) in the serum of cornea donors who had been previously screened by social and medical history by the Eye Bank of Canada, Ontario Division. METHOD:A retrospective examination of the donor records of the Ey...

journal_title：Cornea

authors： Armstrong SA,Gangam N,Chipman ML,Rootman DS

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:Endogenous hyaluronan (HA) has previously been shown to be a part of corneal wound healing after photorefractive keratectomy (PRK). HA is known to bind considerable amounts of water. This study aimed to show whether HA colocalized with water in the wound area after PRK. METHODS:Five New Zealand White rabbits w...

journal_title：Cornea

authors： Weber BA,Fagerholm P,Johansson B

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:We present the clinicopathologic correlations of two case and two other clinical cases of topical anesthetic abuse keratopathy that were originally diagnosed as Acanthamoeba keratitis because of ring keratitis presentation and characteristic history. METHODS:Four patients who were referred to us with suspected...

journal_title：Cornea

authors： Varga JH,Rubinfeld RS,Wolf TC,Stutzman RD,Peele KA,Clifford WS,Madigan W

更新日期：1997-07-01 00:00:00

abstract：PURPOSE:We report a patient with progressive idiopathic, nonulcerative, noninflammatory, avascular, bilateral, paracentral and peripheral corneal thinning monitored for 13 years. METHODS:Because of progressive corneal thinning, the patient underwent several surgical procedures, including an arcuate lamellar keratectom...

journal_title：Cornea

authors： Hagen KB,Waring GO 3rd,Johnson-Wint B

更新日期：1997-07-01 00:00:00

abstract：PURPOSE:Evaluation of contact lens-induced cytologic changes on the conjunctival surface. METHODS:Fifty eyes of 25 patients wearing soft or rigid gas-permeable contact lenses, and 50 healthy eyes of 25 control subjects were examined with conjunctival impression cytology. Of the patients wearing contact lenses, 40% did...

journal_title：Cornea

authors： Adar S,Kanpolat A,Sürücü S,Ucakhan OO

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:To study alterations of the extracellular matrix (ECM) and basement membrane (BM) components in human keratoconus corneas. METHODS:Fifteen normal and 13 keratoconus corneas were characterized by immunofluorescence with antibodies to 23 ECM and BM components. RESULTS:Keratoconus staining patterns for posterior...

journal_title：Cornea

authors： Kenney MC,Nesburn AB,Burgeson RE,Butkowski RJ,Ljubimov AV

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:The purpose of this study was to relate lysosomal enzyme activities in corneal storage media to the outcome of the transplanted corneas. METHODS:Corneal storage media from 358 transplanted corneas were frozen at -70 degrees C and kept for enzyme analysis. Corneas were stored in K-Sol (28), CSM (35), Dexsol (80...

journal_title：Cornea

authors： Wiffen SJ,Hodge DO,Nelson LR,Bruner WE,Bourne WM

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:We sought to illustrate the difficulty in managing uncommon, pigmented mold-related corneal ulceration and to highlight the role of itraconazole in treating these patients. METHOD:We describe the management and clinical course of a patient with a recurring corneal infection caused by Fonsecaea pedrosoi and dis...

journal_title：Cornea

authors： Barton K,Miller D,Pflugfelder SC

更新日期：1997-03-01 00:00:00

abstract：:Confocal microscopy provides a new, noninvasive way of imaging the human cornea in vivo. One of its most important clinical uses is the diagnosis and management of infectious keratitis. The authors used tandem scanning confocal microscopy to image the corneas in two culture-proven cases of Aspergillus keratitis. Funga...

journal_title：Cornea

authors： Winchester K,Mathers WD,Sutphin JE

更新日期：1997-01-01 00:00:00

abstract：:Effective chemotherapy for Acanthamoeba keratitis has been hampered because of the marked resistance of the parasites to a variety of antimicrobial agents. In view of the fact that topical Brolene (propamidine isethionate) and neosporin are currently considered to be the medical treatment of choice in Europe, we sough...

journal_title：Cornea

authors： Alizadeh H,Silvany RE,Meyer DR,Dougherty JM,McCulley JP

更新日期：1997-01-01 00:00:00

abstract：:Fourteen patients presenting with neuropsychiatric manifestations of Wilson's disease were treated with oral tetrathiomolybdate (TM) for 8 weeks followed by oral zinc (Zn) maintenance therapy. The patients were evaluated prospectively at baseline and at yearly intervals for up to 5 years by slit-lamp biomicroscopy and...

journal_title：Cornea

authors： Esmaeli B,Burnstine MA,Martonyi CL,Sugar A,Johnson V,Brewer GJ

更新日期：1996-11-01 00:00:00

abstract：:The records of 39 patients undergoing 40 consecutive penetrating keratoplasties were reviewed to identify donor factors that might correlate with the presence of an epithelial defect on the first postoperative day. Of the 40 transplanted corneas, 13 (32.5%) had no epithelial defect, 18 (45%) had some epithelial defect...

journal_title：Cornea

authors： Kim T,Palay DA,Lynn M

更新日期：1996-09-01 00:00:00

abstract：:Previous studies suggest the existence of two separate and distinct mechanisms of endothelial wound healing (i.e., cell migration and cell spreading), which may be controlled by unique, injury-dependent, wound-related factors. The purpose of our study was to evaluate potential biologic mediators regulating healing of ...

journal_title：Cornea

authors： Petroll WM,Jester JV,Barry-Lane PA,Cavanagh HD

更新日期：1996-09-01 00:00:00

abstract：:We describe the findings in nine Asian-Indian patients with gelatinous droplike corneal dystrophy (GDCD). Most patients showed initial signs of bilateral decreased vision and photophobia at an early age. The siblings were affected in four cases, and parental consanguinity was recorded in seven cases. We classified the...

journal_title：Cornea

authors： Li S,Edward DP,Ratnakar KS,Reddy M,Tso MO

更新日期：1996-07-01 00:00:00

abstract：:Viruses such as human immunodeficiency virus, herpes simplex virus, cytomegalovirus, hepatitis B, hepatitis C, and rabies can be transmitted to the recipient by corneal transplantation. Very few cases of rabies have been reported. Here we report two cases of rabies transmitted by the same donor. Both of the recipients...

journal_title：Cornea

authors： Javadi MA,Fayaz A,Mirdehghan SA,Ainollahi B

更新日期：1996-07-01 00:00:00

abstract：:The objective of this study was to compare four methods of counting corneal endothelial cell density using the Topcon SP 1000 microscope and Image-NET digital graphic software. Two independent observers quantified cell density from 63 endothelial photomicrographs using the various standardized techniques. The first me...

journal_title：Cornea

authors： Vecchi M,Braccio L,Orsoni JG

更新日期：1996-05-01 00:00:00

abstract：:The purpose of this study was to determine whether corneal epithelial defects and epitheliopathy in patients with unilateral dysfunction of the ophthalmic division of the trigeminal nerve (neurotrophic keratitis) is associated with reduced aqueous tear production. Sensation of the skin, cornea, and nasal mucosa, aqueo...

journal_title：Cornea

authors： Heigle TJ,Pflugfelder SC

更新日期：1996-03-01 00:00:00

abstract：:There have been reports of the clearing of sclera that has been grafted into the cornea. This clearing was studied in the rabbit by transplanting full-thickness scleral buttons or by implanting slivers of sclera, both autografts and allografts, into the cornea. Some clearing around the edges of the implanted scleral t...

journal_title：Cornea

authors： Maurice DM,Singh T

更新日期：1996-03-01 00:00:00

abstract：:The iridocorneal-endothelial (ICE) syndrome is characterised clinically by a "hammered-silver" appearance of the corneal endothelium, corneal failure, glaucoma, and iris destruction. Specular photomicroscopic studies of the corneal endothelium have demonstrated a population of abnormal cells termed "ICE cells." The pu...

journal_title：Cornea

authors： Levy SG,Kirkness CM,Moss J,Ficker L,McCartney AC

更新日期：1996-01-01 00:00:00

abstract：:Infectious keratitis after penetrating keratoplasty can be devastating to the survival of the graft and its visual outcome. From November 1989 to October 1994, we treated 41 episodes of late microbial keratitis among 354 consecutive penetrating keratoplasty patients and reviewed their medical records retrospectively. ...

journal_title：Cornea

authors： Tseng SH,Ling KC

更新日期：1995-11-01 00:00:00

abstract：:After n-heptanol removal of the total corneal epithelium and a limbal lamellar keratectomy, 23 rabbit eyes developed features of limbal stem cell deficiency including conjunctival epithelial ingrowth, vascularization and chronic inflammation. One month later, 10 control eyes received a total keratectomy, and 13 experi...

journal_title：Cornea

authors： Kim JC,Tseng SC

更新日期：1995-09-01 00:00:00

abstract：:We report a case of Mycobacterium chelonae keratitis following corneal injury by a foreign body. Diagnosis was made by Ziehl-Neelsen staining and Löwenstein-Jensen culture of corneal scrapings. On the basis of the in vitro susceptibility testing, the patient was treated with topical fortified amikacin. Given the lack ...

journal_title：Cornea

authors： Lois N,Perez del Molino ML

更新日期：1995-09-01 00:00:00

abstract：:The purpose of this study was to evaluate clinical ocular adenoviral isolates for differences among and within serotypes with respect to in vitro infectivity titers and clinical course. The study design included a retrospective chart review and the determination of in vitro infectivity titers (TCID90s) of 90 clinical ...

journal_title：Cornea

authors： Roba LA,Kowalski RP,Gordon AT,Romanowski EG,Gordon YJ

更新日期：1995-07-01 00:00:00

abstract：:This study attempts to measure the quantitative contribution of major chemical fractions of the whole bovine cornea to ultraviolet (UV) absorption between 240 and 300 nm, with special attention to the biologically significant range of 290-300 nm. The cornea was divided into water-insoluble, nonprotein small water-solu...

journal_title：Cornea

authors： Mitchell J,Cenedella RJ

更新日期：1995-05-01 00:00:00

abstract：:The treatment of herpes simplex keratitis has ranged from simple debridement to the use of prototypic antiviral agents specific to the herpes family, such as acyclovir. The various treatment modalities for dendritic keratitis, for the most part, have been effective. However, in recent years numerous reports of antivir...

journal_title：Cornea

authors： Minkovitz JB,Pepose JS

更新日期：1995-05-01 00:00:00

abstract：:The authors sought to determine whether adenovirus could infect human corneal epithelium in vivo. They reviewed the medical records of six patients with adenovirus-positive viral corneal cultures who were examined at the Bascom Palmer Eye Institute between March 21, 1986, and December 31, 1992. The six patients with a...

journal_title：Cornea

authors： Chodosh J,Miller D,Stroop WG,Pflugfelder SC

更新日期：1995-03-01 00:00:00